Pub. Date : 2007 Mar 16
PMID : 17257588
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells. | apicidin | gelsolin | Homo sapiens |
| 2 | In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells. | apicidin | gelsolin | Homo sapiens |
| 3 | Apicidin induces gelsolin mRNA independently of the de novo protein synthesis. | apicidin | gelsolin | Homo sapiens |
| 4 | Furthermore, inhibition of PKCepsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKCepsilon is the major isoform for this process. | apicidin | gelsolin | Homo sapiens |
| 5 | In parallel, apicidin induction of gelsolin is antagonized by the inhibition of Sp1 using dominant-negative Sp1 or specific Sp1 inhibitor mithramycin, and inhibition of PKC leads to suppression of Sp1 promoter activity. | apicidin | gelsolin | Homo sapiens |
| 6 | Our results provide mechanistic insights into molecular mechanisms of gelsolin induction by apicidin. | apicidin | gelsolin | Homo sapiens |