PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17257588-0	2007	PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.	apicidin	81-89	gelsolin	Homo sapiens	28-36	
17257588-2	2007	In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells.	apicidin	148-156	gelsolin	Homo sapiens	102-110	
17257588-3	2007	Apicidin induces gelsolin mRNA independently of the de novo protein synthesis.	apicidin	0-8	gelsolin	Homo sapiens	17-25	
17257588-5	2007	Furthermore, inhibition of PKCepsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKCepsilon is the major isoform for this process.	apicidin	133-141	gelsolin	Homo sapiens	121-129	
17257588-6	2007	In parallel, apicidin induction of gelsolin is antagonized by the inhibition of Sp1 using dominant-negative Sp1 or specific Sp1 inhibitor mithramycin, and inhibition of PKC leads to suppression of Sp1 promoter activity.	apicidin	13-21	gelsolin	Homo sapiens	35-43	
17257588-7	2007	Our results provide mechanistic insights into molecular mechanisms of gelsolin induction by apicidin.	apicidin	92-100	gelsolin	Homo sapiens	70-78