Pub. Date : 2007 May 1
PMID : 17252557
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the epidermal growth factor receptor enhances castration-induced prostate involution and reduces testosterone-stimulated prostate growth in adult rats. | Testosterone | epidermal growth factor receptor | Rattus norvegicus |
| 2 | RESULTS: Both castration alone and testosterone treatment in castrated animals increased the mRNA and protein levels of EGFR and phospho-EGFR in the ventral prostate. | Testosterone | epidermal growth factor receptor | Rattus norvegicus |
| 3 | RESULTS: Both castration alone and testosterone treatment in castrated animals increased the mRNA and protein levels of EGFR and phospho-EGFR in the ventral prostate. | Testosterone | epidermal growth factor receptor | Rattus norvegicus |
| 4 | Inhibition of EGFR during castration and during testosterone-stimulated prostate growth resulted in a decrease in total epithelial weight, epithelial cell proliferation, endothelial cell proliferation, and increased epithelial cell apoptosis. | Testosterone | epidermal growth factor receptor | Rattus norvegicus |
| 5 | CONCLUSIONS: This study suggests that increased EGFR signaling during castration mediates stimulatory effects balancing castration-induced prostate regression, and that EGFR signaling is a necessary component in testosterone-stimulated prostate growth. | Testosterone | epidermal growth factor receptor | Rattus norvegicus |
| 6 | CONCLUSIONS: This study suggests that increased EGFR signaling during castration mediates stimulatory effects balancing castration-induced prostate regression, and that EGFR signaling is a necessary component in testosterone-stimulated prostate growth. | Testosterone | epidermal growth factor receptor | Rattus norvegicus |