PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17252557-0 2007 Inhibition of the epidermal growth factor receptor enhances castration-induced prostate involution and reduces testosterone-stimulated prostate growth in adult rats. Testosterone 111-123 epidermal growth factor receptor Rattus norvegicus 18-50 17252557-4 2007 RESULTS: Both castration alone and testosterone treatment in castrated animals increased the mRNA and protein levels of EGFR and phospho-EGFR in the ventral prostate. Testosterone 35-47 epidermal growth factor receptor Rattus norvegicus 120-124 17252557-4 2007 RESULTS: Both castration alone and testosterone treatment in castrated animals increased the mRNA and protein levels of EGFR and phospho-EGFR in the ventral prostate. Testosterone 35-47 epidermal growth factor receptor Rattus norvegicus 137-141 17252557-5 2007 Inhibition of EGFR during castration and during testosterone-stimulated prostate growth resulted in a decrease in total epithelial weight, epithelial cell proliferation, endothelial cell proliferation, and increased epithelial cell apoptosis. Testosterone 48-60 epidermal growth factor receptor Rattus norvegicus 14-18 17252557-6 2007 CONCLUSIONS: This study suggests that increased EGFR signaling during castration mediates stimulatory effects balancing castration-induced prostate regression, and that EGFR signaling is a necessary component in testosterone-stimulated prostate growth. Testosterone 212-224 epidermal growth factor receptor Rattus norvegicus 48-52 17252557-6 2007 CONCLUSIONS: This study suggests that increased EGFR signaling during castration mediates stimulatory effects balancing castration-induced prostate regression, and that EGFR signaling is a necessary component in testosterone-stimulated prostate growth. Testosterone 212-224 epidermal growth factor receptor Rattus norvegicus 169-173