Title : Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity.

Pub. Date : 2006 Nov-Dec

PMID : 17201164






6 Functional Relationships(s)
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1 Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. Curcumin epidermal growth factor receptor Homo sapiens
2 Other studies indicated that epidermal growth factor receptor (EGFR) is also inhibited by curcumin in vitro and in vivo. Curcumin epidermal growth factor receptor Homo sapiens
3 Other studies indicated that epidermal growth factor receptor (EGFR) is also inhibited by curcumin in vitro and in vivo. Curcumin epidermal growth factor receptor Homo sapiens
4 Our aim was to evaluate whether the curcumin inhibitory effect on the survival of cancer cells is associated with simultaneous down-regulation of COX-2 and EGFR and inhibition of Erk1/2 (extra-cellular signal regulated kinase) signaling pathway. Curcumin epidermal growth factor receptor Homo sapiens
5 In the p34 and PC-14 cells, curcumin decreased COX-2, EGFR and p-Erk1/2 expressions in a dose-dependent manner. Curcumin epidermal growth factor receptor Homo sapiens
6 CONCLUSION: Curcumin co-inhibited COX-2 and EGFR expression and decreased Erk1/2 activity. Curcumin epidermal growth factor receptor Homo sapiens