Title : Domain organization and quaternary structure of the Saccharomyces cerevisiae silent information regulator 3 protein, Sir3p.

Pub. Date : 2006 Dec 26

PMID : 17176117






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Sir3p self-associates extensively in moderate salt and at micromolar protein concentrations producing a broad range of oligomers that sediment from 8 to in excess of 85 S. These results provide new insight into Sir3p domain organization and quaternary structure and support a nucleosome bridging model for Sir3p-dependent regulation of chromatin architecture. Salts chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C