Pub. Date : 2007 Feb
PMID : 17068140
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Short-term nicotine treatment stimulated phosphorylation of p44/42-MAPK, p38-MAPK, and signal transducer and activator of transcription 3. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 2 | However, an additive effect of nicotine pretreatment on insulin stimulation was only observed on p44/42-MAPK. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 3 | The nicotine-induced phosphorylation of p44/42-MAPK and [methyl-(3)H]thymidine incorporation were effectively suppressed by a alpha7-nAChR-selective antagonist, methyllycaconitine, and the phosphorylation of p44/42-MAPK was stimulated by a alpha7-nAChR-specific agonist, GTS21. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 4 | The nicotine-induced phosphorylation of p44/42-MAPK and [methyl-(3)H]thymidine incorporation were effectively suppressed by a alpha7-nAChR-selective antagonist, methyllycaconitine, and the phosphorylation of p44/42-MAPK was stimulated by a alpha7-nAChR-specific agonist, GTS21. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 5 | Interestingly, long-term (48-h) pretreatment with nicotine increased the amount of alpha7-AChR in the plasma membrane and insulin-induced phosphorylation of p44/42-MAPK. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 6 | These results provide the first evidence that acute exposure to nicotine enhances insulin-induced mitogenesis predominantly by affecting the phosphorylation of p44/42-MAPK and that chronic exposure further augments the insulin signal via up-regulation of alpha7-nAChR, which may be crucial for the development and progression of atherosclerosis in large vessels. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |