Pub. Date : 2006 Dec
PMID : 17043164
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The goal of this study was to test the hypothesis that loss of a single copy of the gene for CuZn superoxide dismutase (CuZnSOD) increases vascular superoxide levels and produces vascular dysfunction with aging. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |
| 2 | Vascular superoxide levels were increased in aorta in old CuZnSOD(+/+) mice and increased further in CuZnSOD(+/-) mice with aging. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |
| 3 | Vascular superoxide levels were increased in aorta in old CuZnSOD(+/+) mice and increased further in CuZnSOD(+/-) mice with aging. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |
| 4 | These findings provide the first direct evidence that normal CuZnSOD expression protects endothelial function and that deficiency in a single copy of the gene that encodes CuZnSOD produces increases in superoxide and marked impairment of endothelial function with aging. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |