Pub. Date : 2007 Feb 1
PMID : 16888810
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 2 | To study these mechanisms, the present study focused on nicotine-mediated modulation of the extracellular regulated kinase 1 and 2 (ERK1/2) pathway in cultured spinal cord neurons. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 3 | Exposure to nicotine (0.1-10 microM) for as short as 1 min markedly upregulated levels of phosphorylated ERK1/2 (pERK1/2) and increased total ERK1/2 activity. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 4 | Exposure to nicotine (0.1-10 microM) for as short as 1 min markedly upregulated levels of phosphorylated ERK1/2 (pERK1/2) and increased total ERK1/2 activity. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 5 | In addition, pre-exposure to U0126, a specific inhibitor of the ERK1/2 signaling, prevented nicotine-mediated anti-apoptotic effects. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 6 | To indicate if treatment with nicotine also can activate ERK1/2 in vivo, a moderate spinal cord injury (SCI) was induced in rats using a weight-drop device and nicotine was injected 2 h post-trauma. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 7 | Results of the present study indicate that the ERK1/2 pathway is involved in anti-apoptotic effects of nicotine in spinal cord neurons and may be involved in therapeutic effects of nicotine in spinal cord trauma. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 8 | Results of the present study indicate that the ERK1/2 pathway is involved in anti-apoptotic effects of nicotine in spinal cord neurons and may be involved in therapeutic effects of nicotine in spinal cord trauma. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |