PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16888810-0	2007	ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons.	Nicotine	41-49	mitogen activated protein kinase 3	Rattus norvegicus	0-7	
16888810-2	2007	To study these mechanisms, the present study focused on nicotine-mediated modulation of the extracellular regulated kinase 1 and 2 (ERK1/2) pathway in cultured spinal cord neurons.	Nicotine	56-64	mitogen activated protein kinase 3	Rattus norvegicus	132-138	
16888810-3	2007	Exposure to nicotine (0.1-10 microM) for as short as 1 min markedly upregulated levels of phosphorylated ERK1/2 (pERK1/2) and increased total ERK1/2 activity.	Nicotine	12-20	mitogen activated protein kinase 3	Rattus norvegicus	105-111	
16888810-3	2007	Exposure to nicotine (0.1-10 microM) for as short as 1 min markedly upregulated levels of phosphorylated ERK1/2 (pERK1/2) and increased total ERK1/2 activity.	Nicotine	12-20	mitogen activated protein kinase 3	Rattus norvegicus	114-120	
16888810-5	2007	In addition, pre-exposure to U0126, a specific inhibitor of the ERK1/2 signaling, prevented nicotine-mediated anti-apoptotic effects.	Nicotine	92-100	mitogen activated protein kinase 3	Rattus norvegicus	64-70	
16888810-6	2007	To indicate if treatment with nicotine also can activate ERK1/2 in vivo, a moderate spinal cord injury (SCI) was induced in rats using a weight-drop device and nicotine was injected 2 h post-trauma.	Nicotine	30-38	mitogen activated protein kinase 3	Rattus norvegicus	57-63	
16888810-8	2007	Results of the present study indicate that the ERK1/2 pathway is involved in anti-apoptotic effects of nicotine in spinal cord neurons and may be involved in therapeutic effects of nicotine in spinal cord trauma.	Nicotine	103-111	mitogen activated protein kinase 3	Rattus norvegicus	47-53	
16888810-8	2007	Results of the present study indicate that the ERK1/2 pathway is involved in anti-apoptotic effects of nicotine in spinal cord neurons and may be involved in therapeutic effects of nicotine in spinal cord trauma.	Nicotine	181-189	mitogen activated protein kinase 3	Rattus norvegicus	47-53