Title : Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1).

Pub. Date : 2006 Aug

PMID : 16790529






1 Functional Relationships(s)
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1 Addition of the PI-3 kinase inhibitor LY294002 abrogated this response; moreover, addition of the Akt/PKB inhibitor interleukin (IL)-6-hydroxymethyl-chiro-inositol-2(R)-2-methyl-3-O-octadecylcarbonate prevented p27(Kip-1) phosphorylation in response to CTGF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one cyclin dependent kinase inhibitor 1B Homo sapiens