Title : Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells.

Pub. Date : 2006 Jan

PMID : 16787355






2 Functional Relationships(s)
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1 In the present study we report that PARP-1 inhibitor 3-aminobenzamide (3-AB) increases the cytotoxic activity of the platinum compounds cisplatin, trans-[PtCl(2)(4-picoline)(piperazine)] and transplatin against CH1cisR cisplatin-resistant ovarian tumor cells. Platinum poly(ADP-ribose) polymerase 1 Homo sapiens
2 Altogether, these data suggest that pharmacological modulation of PARP-1 by inhibitors may be a suitable strategy to fight against tumor resistance to platinum drugs. Platinum poly(ADP-ribose) polymerase 1 Homo sapiens