Pub. Date : 1991 Jul 31
PMID : 1677566
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not. | Tetradecanoylphorbol Acetate | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 2 | Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not. | Tetradecanoylphorbol Acetate | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 3 | Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not. | Tetradecanoylphorbol Acetate | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 4 | Transient expression of this active c-erbB-2 stimulated the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, serum response element, and cyclic AMP response element. | Tetradecanoylphorbol Acetate | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 5 | Transient expression of this active c-erbB-2 stimulated the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, serum response element, and cyclic AMP response element. | Tetradecanoylphorbol Acetate | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 6 | Particularly, stimulation of the TPA response element by active c-erbB-2 was prominent. | Tetradecanoylphorbol Acetate | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 7 | Transactivation of the TPA response element was also observed in a cell line that stably expresses active c-erbB-2. | Tetradecanoylphorbol Acetate | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 8 | The active c-erbB-2-induced transactivation of the TPA response element was partially prevented either by down-regulation of protein kinase C or by the protein kinase C inhibitor H7. | Tetradecanoylphorbol Acetate | erb-b2 receptor tyrosine kinase 2 | Mus musculus |