Title : Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa.

Pub. Date : 1991 Mar

PMID : 1672072






2 Functional Relationships(s)
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1 TH synthesized by the implanted fibroblasts appeared to convert tyrosine to L-dopa actively, as observed in vitro, and to affect the host brain, as assessed through a behavioral measurement. Levodopa tyrosine hydroxylase Rattus norvegicus
2 These results suggest that primary fibroblasts genetically altered to express TH have the capacity to deliver L-dopa locally to the striatum in quantities sufficient to compensate partially for the loss of intrinsic striatal dopaminergic input. Levodopa tyrosine hydroxylase Rattus norvegicus