Pub. Date : 2006 Oct
PMID : 16697079
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot analysis showed a great reduction of 5-HT(1A) receptor expression in nicotine mice measured at t=0 (last day of treatment) and at 15 and 30 days after nicotine withdrawal compared to control mice. | Nicotine | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | Western blot analysis showed a great reduction of 5-HT(1A) receptor expression in nicotine mice measured at t=0 (last day of treatment) and at 15 and 30 days after nicotine withdrawal compared to control mice. | Nicotine | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 3 | Our results show that (i) behavioural alterations estimated with forced swimming test and (ii) changes in diencephalic serotonin content and 5-HT(1A) receptor expression, are present since nicotine is withdrawn even after a long time, suggesting a role of serotonin in mood disorders eventually occurring following smoking cessation. | Nicotine | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |