Pub. Date : 2006 May
PMID : 16680587
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid x10(-5) M completely abrogated the proliferative actions of IGF II (70.2% +/- 9.7%, P < 0.05) but had no significant effect on the IGF I response (P > 0.05). | Tretinoin | insulin like growth factor 2 | Homo sapiens |
| 2 | The IGF II inhibitory effect of RA was enhanced in the presence of analogs [Leu27]IGF II (P = 0.052) but not with des(1-6)IGF II (P > 0.05), compared with wild-type IGF II. | Tretinoin | insulin like growth factor 2 | Homo sapiens |
| 3 | The IGF II inhibitory effect of RA was enhanced in the presence of analogs [Leu27]IGF II (P = 0.052) but not with des(1-6)IGF II (P > 0.05), compared with wild-type IGF II. | Tretinoin | insulin like growth factor 2 | Homo sapiens |
| 4 | The IGF II inhibitory effect of RA was enhanced in the presence of analogs [Leu27]IGF II (P = 0.052) but not with des(1-6)IGF II (P > 0.05), compared with wild-type IGF II. | Tretinoin | insulin like growth factor 2 | Homo sapiens |
| 5 | The IGF II inhibitory effect of RA was enhanced in the presence of analogs [Leu27]IGF II (P = 0.052) but not with des(1-6)IGF II (P > 0.05), compared with wild-type IGF II. | Tretinoin | insulin like growth factor 2 | Homo sapiens |
| 6 | CONCLUSIONS: These data implicate a novel antiproliferative role for RA in enhancing the pericellular clearance of IGF II via the IGF2R preventing ligand activation of the IGF I receptor. | Tretinoin | insulin like growth factor 2 | Homo sapiens |