Title : The effects of retinoic acid on the insulin-like growth factor axis in primary tissue culture from hyperparathyroidism.

Pub. Date : 2006 May

PMID : 16680587






6 Functional Relationships(s)
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1 Retinoic acid x10(-5) M completely abrogated the proliferative actions of IGF II (70.2% +/- 9.7%, P < 0.05) but had no significant effect on the IGF I response (P > 0.05). Tretinoin insulin like growth factor 2 Homo sapiens
2 The IGF II inhibitory effect of RA was enhanced in the presence of analogs [Leu27]IGF II (P = 0.052) but not with des(1-6)IGF II (P > 0.05), compared with wild-type IGF II. Tretinoin insulin like growth factor 2 Homo sapiens
3 The IGF II inhibitory effect of RA was enhanced in the presence of analogs [Leu27]IGF II (P = 0.052) but not with des(1-6)IGF II (P > 0.05), compared with wild-type IGF II. Tretinoin insulin like growth factor 2 Homo sapiens
4 The IGF II inhibitory effect of RA was enhanced in the presence of analogs [Leu27]IGF II (P = 0.052) but not with des(1-6)IGF II (P > 0.05), compared with wild-type IGF II. Tretinoin insulin like growth factor 2 Homo sapiens
5 The IGF II inhibitory effect of RA was enhanced in the presence of analogs [Leu27]IGF II (P = 0.052) but not with des(1-6)IGF II (P > 0.05), compared with wild-type IGF II. Tretinoin insulin like growth factor 2 Homo sapiens
6 CONCLUSIONS: These data implicate a novel antiproliferative role for RA in enhancing the pericellular clearance of IGF II via the IGF2R preventing ligand activation of the IGF I receptor. Tretinoin insulin like growth factor 2 Homo sapiens