Title : Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.

Pub. Date : 1991

PMID : 1664202






2 Functional Relationships(s)
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1 Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime. P-2 butyrylcholinesterase Rattus norvegicus
2 Isolated rat diaphragm preparations treated with soman or with the irreversible and oxime resistant cholinesterase (ChE) inhibitor S27 showed a considerable recovery of neuromuscular transmission (NMT) during incubation with the (bis)pyridinium oximes HI-6, HGG-12, P2S and obidoxime. P-2 butyrylcholinesterase Rattus norvegicus