Pub. Date : 2006 Jul
PMID : 16614079
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insulin-like growth factor binding protein 3 has opposing actions on malignant and nonmalignant breast epithelial cells that are each reversible and dependent upon cholesterol-stabilized integrin receptor complexes. | Cholesterol | insulin like growth factor binding protein 3 | Homo sapiens |
| 2 | IGFBP-3 also promoted survival of Hs578T cells in the presence of an antibody to the beta1-integrin subunit or when cholesterol-stabilized complexes were disrupted. | Cholesterol | insulin like growth factor binding protein 3 | Homo sapiens |
| 3 | In contrast, IGFBP-3 promoted growth and survival for nonmalignant MCF-10A cells, but these effects were again reversed on fibronectin and blocked by the beta1 antibody or a MAPK inhibitor or by disruption of cholesterol-stabilized complexes. | Cholesterol | insulin like growth factor binding protein 3 | Homo sapiens |
| 4 | In summary, with three breast epithelial cell lines, IGFBP-3 had positive or negative effects on growth and survival dependent upon the status of cholesterol-stabilized integrin receptor complexes. | Cholesterol | insulin like growth factor binding protein 3 | Homo sapiens |