Pub. Date : 2006 Apr
PMID : 16567507
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In diabetic PPARalpha-knockout mice, renal disease with accompanying albuminuria, glomerular sclerosis, and mesangial area expansion was more severe than in diabetic wild-type mice (P < 0.05) and was accompanied by increased levels of serum free fatty acids and triglycerides (P < 0.01). | Fatty Acids, Nonesterified | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | Taken together, PPARalpha deficiency appears to aggravate the severity of diabetic nephropathy through an increase in extracellular matrix formation, inflammation, and circulating free fatty acid and triglyceride concentrations. | Fatty Acids, Nonesterified | peroxisome proliferator activated receptor alpha | Mus musculus |