Title : Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha.

Pub. Date : 2006 Apr

PMID : 16567507






2 Functional Relationships(s)
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1 In diabetic PPARalpha-knockout mice, renal disease with accompanying albuminuria, glomerular sclerosis, and mesangial area expansion was more severe than in diabetic wild-type mice (P < 0.05) and was accompanied by increased levels of serum free fatty acids and triglycerides (P < 0.01). Fatty Acids, Nonesterified peroxisome proliferator activated receptor alpha Mus musculus
2 Taken together, PPARalpha deficiency appears to aggravate the severity of diabetic nephropathy through an increase in extracellular matrix formation, inflammation, and circulating free fatty acid and triglyceride concentrations. Fatty Acids, Nonesterified peroxisome proliferator activated receptor alpha Mus musculus