Pub. Date : 2006 Mar
PMID : 16567414
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tannic acid, a potent inhibitor of epidermal growth factor receptor tyrosine kinase. | Tannins | epidermal growth factor receptor | Homo sapiens |
| 2 | In the present study, tannic acid was found to strongly inhibit tyrosine kinase activity of epidermal growth factor receptor (EGFr) in vitro (IC50 = 323 nM). | Tannins | epidermal growth factor receptor | Homo sapiens |
| 3 | In the present study, tannic acid was found to strongly inhibit tyrosine kinase activity of epidermal growth factor receptor (EGFr) in vitro (IC50 = 323 nM). | Tannins | epidermal growth factor receptor | Homo sapiens |
| 4 | The inhibition of EGFr tyrosine kinase by tannic acid was competitive with respect to ATP and non-competitive with respect to peptide substrate. | Tannins | epidermal growth factor receptor | Homo sapiens |
| 5 | In cultured cells, growth factor-induced tyrosine phosphorylation of growth factor receptors, including EGFr, platelet-derived growth factor receptor, and basic fibroblast growth factor receptor, was inhibited by tannic acid. | Tannins | epidermal growth factor receptor | Homo sapiens |
| 6 | The molecular modeling study suggested that tannic acid could be docked into the ATP binding pockets of either EGFr or insulin receptor. | Tannins | epidermal growth factor receptor | Homo sapiens |
| 7 | These results demonstrate that tannic acid is an in vitro potent inhibitor of EGFr tyrosine kinase. | Tannins | epidermal growth factor receptor | Homo sapiens |