Pub. Date : 2006 Jul 1
PMID : 16522817
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 2 | It was recently shown that maturation of DCs in the presence of PGE2 results in upregulation of indoleamine 2,3-dioxygenase (IDO) providing a potential mechanism for the development of DC-mediated Tcell tolerance. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 3 | It was recently shown that maturation of DCs in the presence of PGE2 results in upregulation of indoleamine 2,3-dioxygenase (IDO) providing a potential mechanism for the development of DC-mediated Tcell tolerance. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 4 | Here, we extend these findings, demonstrating a concomitant induction of IDO and secretion of soluble CD25 after DC maturation in the presence of PGE2. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 5 | While maturation of DCs induced IDO expression on transcriptional level, only integration of PGE2 signaling led to up-regulation of functional IDO protein as well as significant expression of cell-surface and soluble CD25 protein. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 6 | Of importance, we demonstrate that different carcinoma entities associated with elevated levels of PGE2 coexpress CD25 and IDO in peritumoral dendritic cells, suggesting that PGE2 might influence IDO expression in human DCs in the tumor environment. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 7 | Of importance, we demonstrate that different carcinoma entities associated with elevated levels of PGE2 coexpress CD25 and IDO in peritumoral dendritic cells, suggesting that PGE2 might influence IDO expression in human DCs in the tumor environment. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 8 | Of importance, we demonstrate that different carcinoma entities associated with elevated levels of PGE2 coexpress CD25 and IDO in peritumoral dendritic cells, suggesting that PGE2 might influence IDO expression in human DCs in the tumor environment. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 9 | Of importance, we demonstrate that different carcinoma entities associated with elevated levels of PGE2 coexpress CD25 and IDO in peritumoral dendritic cells, suggesting that PGE2 might influence IDO expression in human DCs in the tumor environment. | Dinoprostone | indoleamine 2,3-dioxygenase 1 | Homo sapiens |