Protein Name indoleamine 2,3-dioxygenase 1
Organism Homo sapiens
Gene ID 3620
Gene Symbol

IDO1

UniProt P14902 (I23O1_HUMAN), A0A348GSI3 (A0A348GSI3_HUMAN)
Relationships Total Number of functionally related compound(s) : 790
Total Number of Articles : 1589
Description

indoleamine 2,3-dioxygenase 1

Gene Summary

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

synonyms
  • indoleamine 2,3-dioxygenase 1
  • indolamine 2,3 dioxygenase
  • indole 2,3-dioxygenase
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Properties