Title : Epidermal growth factor receptor activation by epidermal growth factor mediates oxidant-induced goblet cell metaplasia in human airway epithelium.

Pub. Date : 2006 May

PMID : 16424381






2 Functional Relationships(s)
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1 ROS-induced EGFR activation resulted in GC proliferation and increased MUC5AC gene and protein expression. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens
2 In conclusion, ROS-induced GC metaplasia in normal human bronchial epithelial cells is associated with HA depolymerization and EGF processing by TK followed by EGFR signaling, suggesting that increases in TK activity could contribute to GC metaplasia and mucus hypersecretion in diseases such as asthma and chronic bronchitis. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens