Pub. Date : 2005 Dec
PMID : 16418063
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Styrene monomer primarily induces CYP2B1 mRNA in rat liver. | Styrene | cytochrome P450, family 2, subfamily b, polypeptide 1 | Rattus norvegicus |
| 2 | The amount of CYP2B1 mRNA was significantly increased, 47-fold compared with controls, suggesting that this CYP is the primary cytochrome P450 in rats exposed to styrene. | Styrene | cytochrome P450, family 2, subfamily b, polypeptide 1 | Rattus norvegicus |
| 3 | Western blot analysis also indicated that the protein levels of CYP2B1, CYP2B2, CYP2E1 and CYP1A2 showed clear increases after styrene treatment, corresponding to their mRNA expression. | Styrene | cytochrome P450, family 2, subfamily b, polypeptide 1 | Rattus norvegicus |
| 4 | The results demonstrate that CYP2B1 is the primarily induced CYP form by styrene treatment to rats at acute toxic level. | Styrene | cytochrome P450, family 2, subfamily b, polypeptide 1 | Rattus norvegicus |