Pub. Date : 2006 Jan 11
PMID : 16407535
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The levels of dopamine and its major metabolites in the nucleus accumbens were markedly increased by the microinjection of orexin A and orexin B into the VTA. | Dopamine | hypocretin | Mus musculus |
| 2 | The levels of dopamine and its major metabolites in the nucleus accumbens were markedly increased by the microinjection of orexin A and orexin B into the VTA. | Dopamine | hypocretin | Mus musculus |
| 3 | Furthermore, the increased level of dialysate dopamine produced by morphine in the mouse brain was significantly decreased by deletion of the prepro-orexin gene. | Dopamine | hypocretin | Mus musculus |
| 4 | These findings provide new evidence that orexin-containing neurons in the VTA are directly implicated in the rewarding effect and hyperlocomotion induced by morphine through activation of the mesolimbic dopamine pathway in rodents. | Dopamine | hypocretin | Mus musculus |