Protein Name hypocretin
Organism Mus musculus
Gene ID 15171
Gene Symbol


UniProt O55241 (OREX_MOUSE), Q547R2 (Q547R2_MOUSE)
Relationships Total Number of functionally related compound(s) : 193
Total Number of Articles : 266


Gene Summary

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]

  • hypocretin neuropeptide precursor
  • hypocretin neuropeptide
  • orexin A
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