Title : Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment.

Pub. Date : 2006 Jun

PMID : 16387351






2 Functional Relationships(s)
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1 Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment. Cisplatin mitogen-activated protein kinase 14 Homo sapiens
2 The simultaneous study of activation pattern of key proteins of different signaling pathways revealed that cisplatin induced both activation of ERK and p38 and inhibition of P-FAK in the sensitive cells, whereas it progressively failed to elicit such a response in the resistant variants. Cisplatin mitogen-activated protein kinase 14 Homo sapiens