Title : Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.

Pub. Date : 2006 Mar

PMID : 16385087






3 Functional Relationships(s)
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1 Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta-induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs. Metformin nuclear factor kappa B subunit 1 Homo sapiens
2 Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta-induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs. Metformin nuclear factor kappa B subunit 1 Homo sapiens
3 CONCLUSIONS: These data suggest that metformin can exert a direct vascular anti-inflammatory effect by inhibiting NF-kappaB through blockade of the PI3K-Akt pathway. Metformin nuclear factor kappa B subunit 1 Homo sapiens