Pub. Date : 2006 Mar
PMID : 16385087
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta-induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta-induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | CONCLUSIONS: These data suggest that metformin can exert a direct vascular anti-inflammatory effect by inhibiting NF-kappaB through blockade of the PI3K-Akt pathway. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |