PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16385087-5 2006 Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta-induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs. Metformin 64-73 nuclear factor kappa B subunit 1 Homo sapiens 142-164 16385087-5 2006 Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta-induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs. Metformin 64-73 nuclear factor kappa B subunit 1 Homo sapiens 166-175 16385087-9 2006 CONCLUSIONS: These data suggest that metformin can exert a direct vascular anti-inflammatory effect by inhibiting NF-kappaB through blockade of the PI3K-Akt pathway. Metformin 37-46 nuclear factor kappa B subunit 1 Homo sapiens 114-123