Pub. Date : 2006 Feb 24
PMID : 16377633
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | From pharmacological analysis of the recombinant T-type channels, low concentrations (<50 microM) of nickel were found to selectively block the Ca(v)3.2 over the other isoforms. | Nickel | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 2 | To date, however, the structural element(s) responsible for the nickel block on the Ca(v)3.2 T-type Ca2+ channel remain unknown. | Nickel | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 3 | Thus, we constructed chimeric channels between the nickel-sensitive Ca(v)3.2 and the nickel-insensitive Ca(v)3.1 to localize the region interacting with nickel. | Nickel | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 4 | Systematic assaying of serial chimeras suggests that the region preceding domain I S4 of Ca(v)3.2 contributes to nickel block. | Nickel | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 5 | Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1. | Nickel | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 6 | Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1. | Nickel | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 7 | Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1. | Nickel | immunoglobulin lambda variable 7-43 | Homo sapiens |
| 8 | These findings indicate that His-191 in the S3-S4 loop is a critical residue conferring nickel block to Ca(v)3.2 and reveal a novel role for the S3-S4 loop to control ion permeation through T-type Ca2+ channels. | Nickel | immunoglobulin lambda variable 7-43 | Homo sapiens |