PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16377633-2	2006	From pharmacological analysis of the recombinant T-type channels, low concentrations (<50 microM) of nickel were found to selectively block the Ca(v)3.2 over the other isoforms.	Nickel	104-110	immunoglobulin lambda variable 7-43	Homo sapiens	147-155	
16377633-3	2006	To date, however, the structural element(s) responsible for the nickel block on the Ca(v)3.2 T-type Ca2+ channel remain unknown.	Nickel	64-70	immunoglobulin lambda variable 7-43	Homo sapiens	84-92	
16377633-4	2006	Thus, we constructed chimeric channels between the nickel-sensitive Ca(v)3.2 and the nickel-insensitive Ca(v)3.1 to localize the region interacting with nickel.	Nickel	51-57	immunoglobulin lambda variable 7-43	Homo sapiens	68-76	
16377633-5	2006	Systematic assaying of serial chimeras suggests that the region preceding domain I S4 of Ca(v)3.2 contributes to nickel block.	Nickel	113-119	immunoglobulin lambda variable 7-43	Homo sapiens	89-97	
16377633-6	2006	Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1.	Nickel	29-35	immunoglobulin lambda variable 7-43	Homo sapiens	149-157	
16377633-6	2006	Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1.	Nickel	133-139	immunoglobulin lambda variable 7-43	Homo sapiens	149-157	
16377633-6	2006	Point mutations of potential nickel-interacting sites revealed that H191Q in the S3-S4 loop of domain I significantly attenuated the nickel block of Ca(v)3.2, mimicking the nickel-insensitive blocking potency of Ca(v)3.1.	Nickel	133-139	immunoglobulin lambda variable 7-43	Homo sapiens	149-157	
16377633-7	2006	These findings indicate that His-191 in the S3-S4 loop is a critical residue conferring nickel block to Ca(v)3.2 and reveal a novel role for the S3-S4 loop to control ion permeation through T-type Ca2+ channels.	Nickel	88-94	immunoglobulin lambda variable 7-43	Homo sapiens	104-112