PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16357177-4 2005 Here, we show that bortezomib promotes apoptosis triggered by classic ER stress inducers (tunicamycin and thapsigargin) via a c-Jun NH(2)-terminal kinase (JNK)-dependent mechanism. Bortezomib 19-29 mitogen-activated protein kinase 8 Homo sapiens 126-153 16357177-4 2005 Here, we show that bortezomib promotes apoptosis triggered by classic ER stress inducers (tunicamycin and thapsigargin) via a c-Jun NH(2)-terminal kinase (JNK)-dependent mechanism. Bortezomib 19-29 mitogen-activated protein kinase 8 Homo sapiens 155-158 16357177-6 2005 Importantly, combined therapy with bortezomib plus cisplatin induced JNK activation and apoptosis in orthotopic pancreatic tumors resulting in a reduction in tumor burden. Bortezomib 35-45 mitogen-activated protein kinase 8 Homo sapiens 69-72