Pub. Date : 2006 May 11
PMID : 16331246
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Ciota-mediated attenuation of p38 MAP kinase signaling. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | The expression of both GMFbeta mRNA and protein increased upon PKCiota depletion, and this was accompanied by an increase in cisplatin-activated p38 MAP kinase signaling. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Transient overexpression of GMFbeta increased cisplatin-activated p38 MAP kinase signaling and also sensitised cells to cisplatin cytotoxicity. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | The increase in cisplatin cytotoxicity seen with PKCiota depletion was blocked by the p38 MAP kinase inhibitor SKF86002. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | These data show that PKCiota can confer partial resistance to cisplatin in glioblastoma cells by suppressing GMFbeta-mediated enhancement of p38 MAP kinase signaling. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |