Title : Mutation P732L in human DNA topoisomerase IIbeta abolishes DNA cleavage in the presence of calcium and confers drug resistance.

Pub. Date : 2006 Jan

PMID : 16239602






2 Functional Relationships(s)
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1 The anti cancer drug methyl N-(4"-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide (mAMSA) targets human DNA topoisomerase IIbeta. Amsacrine DNA topoisomerase II beta Homo sapiens
2 Random mutagenesis of human DNA topoisomerase IIbeta cDNA, followed by selection in yeast for resistance to mAMSA, identified betaP732L. Amsacrine DNA topoisomerase II beta Homo sapiens