Pub. Date : 2005 Nov
PMID : 16216590
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glimepiride induces nitric oxide production in human coronary artery endothelial cells via a PI3-kinase-Akt dependent pathway. | glimepiride | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The effects of LY294002, a specific PI3-kinase inhibitor, and antisense oligonucleotides directed to Akt, on glimepiride-induced NO production were examined. | glimepiride | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Akt was rapidly phosphorylated by glimepiride and antisense oligonucleotides directed to Akt completely inhibited glimepiride-induced NO production. | glimepiride | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Akt was rapidly phosphorylated by glimepiride and antisense oligonucleotides directed to Akt completely inhibited glimepiride-induced NO production. | glimepiride | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Akt was rapidly phosphorylated by glimepiride and antisense oligonucleotides directed to Akt completely inhibited glimepiride-induced NO production. | glimepiride | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | These data demonstrate that glimepiride induces NO production in HCAECs by activating PI3-kinase and Akt, and also suggest that use of glimepiride in type 2 diabetes may show promise for preventing CAD in addition to lowering glucose levels. | glimepiride | AKT serine/threonine kinase 1 | Homo sapiens |