PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16216590-0	2005	Glimepiride induces nitric oxide production in human coronary artery endothelial cells via a PI3-kinase-Akt dependent pathway.	glimepiride	0-11	AKT serine/threonine kinase 1	Homo sapiens	104-107	
16216590-7	2005	The effects of LY294002, a specific PI3-kinase inhibitor, and antisense oligonucleotides directed to Akt, on glimepiride-induced NO production were examined.	glimepiride	109-120	AKT serine/threonine kinase 1	Homo sapiens	101-104	
16216590-10	2005	Akt was rapidly phosphorylated by glimepiride and antisense oligonucleotides directed to Akt completely inhibited glimepiride-induced NO production.	glimepiride	34-45	AKT serine/threonine kinase 1	Homo sapiens	0-3	
16216590-10	2005	Akt was rapidly phosphorylated by glimepiride and antisense oligonucleotides directed to Akt completely inhibited glimepiride-induced NO production.	glimepiride	114-125	AKT serine/threonine kinase 1	Homo sapiens	0-3	
16216590-10	2005	Akt was rapidly phosphorylated by glimepiride and antisense oligonucleotides directed to Akt completely inhibited glimepiride-induced NO production.	glimepiride	114-125	AKT serine/threonine kinase 1	Homo sapiens	89-92	
16216590-11	2005	These data demonstrate that glimepiride induces NO production in HCAECs by activating PI3-kinase and Akt, and also suggest that use of glimepiride in type 2 diabetes may show promise for preventing CAD in addition to lowering glucose levels.	glimepiride	28-39	AKT serine/threonine kinase 1	Homo sapiens	101-104