Pub. Date : 2005 Oct 6
PMID : 16190759
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners. | Hydantoins | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 2 | Discovery of a highly selective, potent, and safe non-carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions has been a long-standing challenge. | Hydantoins | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 3 | Discovery of a highly selective, potent, and safe non-carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions has been a long-standing challenge. | Hydantoins | aldo-keto reductase family 1 member B1 | Rattus norvegicus |