| Protein Name | aldo-keto reductase family 1 member B1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24192 |
| Gene Symbol | Akr1b1 |
| UniProt | P07943 (ALDR_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
527
Total Number of Articles : 728 |
Description |
aldo-keto reductase family 1 member B1 |
| Gene Summary |
Enables aldose reductase (NADPH) activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including cellular response to peptide; inner medullary collecting duct development; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Jun 2025] |
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