Pub. Date : 2005 Sep
PMID : 16156793
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5. | Polyphenols | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 2 | At nontoxic concentrations, several of the polyphenols were able to modulate MRP1-, MRP4- and MRP5-mediated drug resistance, though to varying extents. | Polyphenols | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 3 | The polyphenols also reversed resistance to NSC251820, a compound that appears to be a good substrate for MRP4, as predicted by data-mining studies. | Polyphenols | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 4 | Furthermore, most of the polyphenols showed direct inhibition of MRP1-mediated [3H]dinitrophenyl S-glutathione and MRP4-mediated [3H]cGMP transport in inside-out vesicles prepared from human erythrocytes. | Polyphenols | ATP binding cassette subfamily C member 4 | Homo sapiens |