Title : Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

Pub. Date : 2005 Sep

PMID : 16156793






4 Functional Relationships(s)
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1 This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5. Polyphenols ATP binding cassette subfamily C member 4 Homo sapiens
2 At nontoxic concentrations, several of the polyphenols were able to modulate MRP1-, MRP4- and MRP5-mediated drug resistance, though to varying extents. Polyphenols ATP binding cassette subfamily C member 4 Homo sapiens
3 The polyphenols also reversed resistance to NSC251820, a compound that appears to be a good substrate for MRP4, as predicted by data-mining studies. Polyphenols ATP binding cassette subfamily C member 4 Homo sapiens
4 Furthermore, most of the polyphenols showed direct inhibition of MRP1-mediated [3H]dinitrophenyl S-glutathione and MRP4-mediated [3H]cGMP transport in inside-out vesicles prepared from human erythrocytes. Polyphenols ATP binding cassette subfamily C member 4 Homo sapiens