Title : Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme.

Pub. Date : 2005 Sep 15

PMID : 16148149






1 Functional Relationships(s)
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1 We hypothesize that HNE activates TACE via ROS generation, resulting in cleavage of pro-TGF-alpha, EGFR activation, and MUC5AC mucin expression in airway epithelial cells. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens