Pub. Date : 2005 Sep 1
PMID : 16140980
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 2 | (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 3 | (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 4 | (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 5 | (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 6 | Pretreatment of KYSE 150 cells with EGCG (20 micromol/L) for 0.5 to 24 hours in HAM"s F12 and RPMI 1640 mixed medium at 37 degrees C, before the addition of EGF, resulted in a decreased level of phosphorylated EGFR (by 32-85%). | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 7 | Prolonged treatment with EGCG (8 or 24 hours) also decreased EGFR protein level (both by 80%). | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 8 | The results suggest that in cell culture conditions, the auto-oxidation of EGCG leads to EGFR inactivation, but the inhibition of cell growth is due to other mechanisms. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |