PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16140980-0 2005 Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells. epigallocatechin gallate 23-53 epidermal growth factor receptor Homo sapiens 96-128 16140980-1 2005 (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). epigallocatechin gallate 0-30 epidermal growth factor receptor Homo sapiens 180-212 16140980-1 2005 (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). epigallocatechin gallate 0-30 epidermal growth factor receptor Homo sapiens 214-218 16140980-1 2005 (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). epigallocatechin gallate 32-36 epidermal growth factor receptor Homo sapiens 180-212 16140980-1 2005 (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). epigallocatechin gallate 32-36 epidermal growth factor receptor Homo sapiens 214-218 16140980-3 2005 Pretreatment of KYSE 150 cells with EGCG (20 micromol/L) for 0.5 to 24 hours in HAM"s F12 and RPMI 1640 mixed medium at 37 degrees C, before the addition of EGF, resulted in a decreased level of phosphorylated EGFR (by 32-85%). epigallocatechin gallate 36-40 epidermal growth factor receptor Homo sapiens 210-214 16140980-4 2005 Prolonged treatment with EGCG (8 or 24 hours) also decreased EGFR protein level (both by 80%). epigallocatechin gallate 25-29 epidermal growth factor receptor Homo sapiens 61-65 16140980-12 2005 The results suggest that in cell culture conditions, the auto-oxidation of EGCG leads to EGFR inactivation, but the inhibition of cell growth is due to other mechanisms. epigallocatechin gallate 75-79 epidermal growth factor receptor Homo sapiens 89-93