Pub. Date : 2004 Oct
PMID : 16134002
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cyclooxygenase-2 inhibitor celecoxib is a potent inhibitor of human carbonic anhydrase II. | Celecoxib | carbonic anhydrase 2 | Homo sapiens |
| 2 | In the present study, we report that celecoxib exhibits the characteristics of a potent CA inhibitor, showing inhibitory human carbonic anhydrase II (hCAII) activity in the nanomolar range. | Celecoxib | carbonic anhydrase 2 | Homo sapiens |
| 3 | In the present study, we report that celecoxib exhibits the characteristics of a potent CA inhibitor, showing inhibitory human carbonic anhydrase II (hCAII) activity in the nanomolar range. | Celecoxib | carbonic anhydrase 2 | Homo sapiens |
| 4 | These data showing inhibition of hCAII by the unsubstituted sulfonamides celecoxib and valdecoxib, but not by rofecoxib, may have important implications for the elucidation of the mechanisms of action as well as the side effects associated with COX-2 inhibitors. | Celecoxib | carbonic anhydrase 2 | Homo sapiens |