PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16134002-0 2004 The cyclooxygenase-2 inhibitor celecoxib is a potent inhibitor of human carbonic anhydrase II. Celecoxib 31-40 carbonic anhydrase 2 Homo sapiens 72-93 16134002-8 2004 In the present study, we report that celecoxib exhibits the characteristics of a potent CA inhibitor, showing inhibitory human carbonic anhydrase II (hCAII) activity in the nanomolar range. Celecoxib 37-46 carbonic anhydrase 2 Homo sapiens 127-148 16134002-8 2004 In the present study, we report that celecoxib exhibits the characteristics of a potent CA inhibitor, showing inhibitory human carbonic anhydrase II (hCAII) activity in the nanomolar range. Celecoxib 37-46 carbonic anhydrase 2 Homo sapiens 150-155 16134002-12 2004 These data showing inhibition of hCAII by the unsubstituted sulfonamides celecoxib and valdecoxib, but not by rofecoxib, may have important implications for the elucidation of the mechanisms of action as well as the side effects associated with COX-2 inhibitors. Celecoxib 73-82 carbonic anhydrase 2 Homo sapiens 33-38