Pub. Date : 2005 Dec 15
PMID : 16084497
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DARPP-32 phosphorylation opposes the behavioral effects of nicotine. | Nicotine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 2 | Because post-synaptic neurons within the striatum contain high levels of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), we hypothesized that DARPP-32 may functionally contribute to the behavioral effects of nicotine. | Nicotine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 3 | Because post-synaptic neurons within the striatum contain high levels of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), we hypothesized that DARPP-32 may functionally contribute to the behavioral effects of nicotine. | Nicotine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 4 | Because post-synaptic neurons within the striatum contain high levels of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), we hypothesized that DARPP-32 may functionally contribute to the behavioral effects of nicotine. | Nicotine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 5 | Systemic injections of nicotine resulted in increased striatal DARPP-32 phosphorylation at threonine34 and threonine75. | Nicotine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 6 | CONCLUSIONS: DARPP-32 opposes the behavioral effects of nicotine possibly via concurrent phosphorylation at the two threonine sites. | Nicotine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |