PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16084497-0 2005 DARPP-32 phosphorylation opposes the behavioral effects of nicotine. Nicotine 59-67 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 0-8 16084497-2 2005 Because post-synaptic neurons within the striatum contain high levels of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), we hypothesized that DARPP-32 may functionally contribute to the behavioral effects of nicotine. Nicotine 230-238 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 77-130 16084497-2 2005 Because post-synaptic neurons within the striatum contain high levels of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), we hypothesized that DARPP-32 may functionally contribute to the behavioral effects of nicotine. Nicotine 230-238 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 132-140 16084497-2 2005 Because post-synaptic neurons within the striatum contain high levels of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), we hypothesized that DARPP-32 may functionally contribute to the behavioral effects of nicotine. Nicotine 230-238 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 164-172 16084497-9 2005 Systemic injections of nicotine resulted in increased striatal DARPP-32 phosphorylation at threonine34 and threonine75. Nicotine 23-31 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 63-71 16084497-10 2005 CONCLUSIONS: DARPP-32 opposes the behavioral effects of nicotine possibly via concurrent phosphorylation at the two threonine sites. Nicotine 56-64 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 13-21