Title : Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells.

Pub. Date : 2005 Jun 1

PMID : 15896333






3 Functional Relationships(s)
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1 Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells. sulforaphane mitogen-activated protein kinase 1 Homo sapiens
2 Additionally, the roles of PI3K/Akt and MEK/ERK signaling pathways have been assessed in these sulforaphane- and erucin-induced events. sulforaphane mitogen-activated protein kinase 1 Homo sapiens
3 Taken together, these results demonstrate that PI3K/Akt and MEK/ERK signals are important intracellular mediators in erucin- and sulforaphane-mediated phase II enzyme transcription and cell cycle arrest in Caco-2 cells. sulforaphane mitogen-activated protein kinase 1 Homo sapiens