Title : Inhibition of cytokine-induced IkappaB kinase activation as a mechanism contributing to the anti-atherogenic activity of tilianin in hyperlipidemic mice.

Pub. Date : 2005 May

PMID : 15823272






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Tilianin has been shown to down-regulate TNF-alpha induced expression of vascular cell adhesion molecules in endothelial cells. tilianin tumor necrosis factor Mus musculus
2 Primary cultured peritoneal macrophages from Ldlr-/- mice showed increased level of TNF-alpha andIL-1beta mRNA in response to treatment with lipopolysaccharide; these increases were inhibited by co-treatment with tilianin. tilianin tumor necrosis factor Mus musculus
3 These results suggest that tilianin ameliorates atherosclerosis by inhibiting the production of the NF-kappaB-dependent pro-inflammatory cytokines, TNF-alpha and IL-1beta, via the inhibition of IkappaB kinase activity. tilianin tumor necrosis factor Mus musculus